2003 MAY 5 - (NewsRx.com & NewsRx.net) -- UVA radiation treated immortalized keratinocytes creates GSH efflux, increasing intracellular oxidative stress and apoptosis.
"We have investigated the role played by GSH efflux in apoptosis of human HaCaT keratinocytes induced by UVA irradiation. UVA irradiation of HaCaT cells caused a rapid rise in GSH efflux across the intact cell membrane, followed by an increase in apoptosis.
"GSH efflux was stimulated by glucose and was reduced by the addition of exogenous GSH and intracellular GSH depletion by buthionine sulfoximine, suggesting that GSH transport is active and is influenced by the GSH concentration gradient …
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